Researcher

Álvaro Ardiles Araya

alvaro.ardiles@uv.cl

Affiliation

Department of Pathology and Physiology, School of Medicine, Universidad de Valparaíso, Chile.

Academic Background

  • Bachelor in Biochemistry (Pontificia Universidad Católica de Valparaíso)
  • Biochemist (Pontificia Universidad Católica de Valparaíso)
  • PhD in Neuroscience (Universidad de Valparaíso)

Álvaro Ardiles is a biochemist from the Pontificia Universidad Católica de Valparaíso and holds a PhD in Science, specialising in Neuroscience, from the Universidad de Valparaíso. He undertook post-doctorate research at the Valparaíso Interdisciplinary Neuroscience Centre and is currently an associate researcher there. He works as an associate professor at the School of Medicine at the Universidad de Valparaíso and is a professor on the Medicine and Medical Technology courses at the Universidad de Valparaíso. He is also a member of the teaching staff of the Neuroscience and Cellular and Molecular Biology Master’s programmes as well as the Doctorate programmes in Neuroscience and in Health Sciences and Engineering at the Universidad de Valparaíso. He conducts basic preclinical research in the field of ageing and his primary line of research is aimed at understanding the molecular mechanisms associated with neurodegenerative synaptopathies such as Alzheimer’s disease.

Link research

Works

Publications

Carolina Flores-Muñoz, Francisca García-Rojas, Miguel A. Perez, Odra Santander, Elena Mery, Stefany Órdenes, Javiera Illanes-González, Arlek M. Gonzalez-Jamett, Marco Fuenzalida, Agustín D. Martinez and Álvaro O. Ardiles. (2022). The long-term Pannexin 1 ablation produces structural and functional modifications in hippocampal neurons. Accepted in Cells.

Felipe Cabral-Miranda, Giovani Tamburini, Gabriela Martinez, Danilo Medinas, Yannis Gerakis, Claudia Duran-Aniotz, Alvaro O. Ardiles, Cristobal Gonzalez, Carleen Sabusap, Francisca Bermedo-Garcia, Stuart Adamson, Kaitlyn Vitangcol, Hernan Huerta, Sergio Pablo Sardi, Brian K. Kenedy, Julio Cesar Cárdenas, Adrian G. Palacios, Lars Plate, Juan Pablo Henriquez, and Claudio Hetz. (2022). Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. The EMBO Journal, e111952. https://doi.org/10.15252/embj.2022111952

Buendía D, Guncay T, Oyanedel M, Lemus M, Weinstein A, Ardiles ÁO, Marcos J, Fernandes A, Zângaro R, Muñoz P. (2022). The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model. Brain Sci. 12(10):1272. doi: 10.3390/brainsci12101272.

Mihalas S, Ardiles A, He K, Palacios A, Kirkwood A. (2021). A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity. Front Synaptic Neurosci. 13:703621. doi: 10.3389/fnsyn.2021.703621.

Ardiles ÁO, Arancibia M, Lutz M, Riquelme J, Gigoux JP, Muñoz P. (2021). Aducanumab: Lack of consistency between preclinical and clinical evidence. Rev Med Chil. 149(6):950-951. doi: 10.4067/s0034-98872021000600950.

Jorge Arriagada-Diaz, Lorena Prado-Vega, Ana M. Cárdenas Díaz, Alvaro O. Ardiles and Arlek M. Gonzalez-Jamett. (2021). Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease. The Neuroscientist 1–18. https://doi.org/10.1177/1073858420974313.

Carolina Flores-Muñoz, Bárbara Gómez, Elena Mery, Ivana Gajardo, Paula Mujica, Claudio Córdova, Daniela López-Espíndola, Claudia Durán-Aniotz, Claudio Hetz, Pablo Muñoz Arlek González-Jamett, and Álvaro O. Ardiles. (2020). Acute Pannexin 1 blockade mitigates early synaptic plasticity deficits in Alzheimer’s disease model. Front. Cell. Neurosci. 14:46. doi: 10.3389/fncel.2020.00046

Lily Yu-Li Chang, Alvaro O. Ardiles, Cheril Tapia-Rojas, Joaquín Araya, Nibaldo C. Inestrosa, Adrian G Palacios and Monica Liliana Acosta. (2020). Evidence of synaptic and neurochemical remodeling in the retina of ageing degus. Front. Neurosci. 14:161. doi: 10.3389/fnins.2020.00161

Gajardo I, Salazar CS, Lopez-Espíndola D, Estay C, Flores-Muñoz C, Gonzalez-Jamett AM, Martínez AD, Muñoz P, and Ardiles AO. (2018). Lack of Pannexin 1 alters synaptic GluN2 subunit composition and spatial reversal learning in mice. Front Mol Neurosci. 11: 114.

Ardiles AO, Grabrucker AM, Scholl FG, Rudenko G, Borsello T. (2017). Molecular and Cellular Mechanisms of Synaptopathies. Neural Plast. 2017:2643943.

Claudia Duran-Aniotz, Victor Hugo Cornejo, Sandra Espinoza, Álvaro O. Ardiles, Danilo B. Medinas, Claudia Salazar, Andrew Foley, Ivana Gajardo, Peter Thielen, Takao Iwawaki, Wiep Scheper, Claudio Soto, Adrian G. Palacios Jeroen J.  M. Hoozemans, and Claudio Hetz. (2017). IRE1 signaling exacerbates Alzheimer’s disease pathogenesis. Acta Neuropathol. 134 (3):489–506.

Pablo Muñoz, Carolina Estay, Paula Díaz, Claudio Elgueta, Álvaro O. Ardiles, and Pablo A. Lizana. (2016). Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats. Neural Plast. 2016:4783836

Salazar C, Valdivia G, Ardiles ÁO, Ewer J, Palacios AG. (2016). Genetic variants associated with neurodegenerative Alzheimer disease in natural models. Biol Res. 49:14.

Gabriela Martínez, René L. Vidal, Pablo Mardones, Felipe G. Serrano, Alvaro O. Ardiles, Craig Wirth, Claudia Molina, Pamela Valdés, Peter Thielen, Cecilia Hidalgo, Bernard L. Schneider, Bredford Kerr, Jose Luis Valdés, Adrian G. Palacios, Nibaldo C. Inestrosa, Laurie H. Glimcher and Claudio Hetz. (2016). Regulation of memory formation by the transcription factor XBP1. Cell reports 14:1-13.

Hui Huang, Alvaro O. Ardiles, Sunggu Wang, Gonzalo Valdivia, Min Baek, Adrian Palacios, Michela Gallagher and Alfredo Kirkwood. (2016).  Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the hippocampus. J. Neurosci. 36:1723 –1729.

Lucia Y. Du, Lily Y-L. Chang, Alvaro O. Ardiles, Cheril Tapia-Rojas, Joaquin Araya, Nibaldo C. Inestrosa, Adrian G. Palacios, Monica L. Acosta. (2015). Alzheimer’s disease-related protein expression in the retina of aged Octodon degus. Plos One 10(8):e0135499.

Inestrosa NC, Ríos JA, Cisternas P, Tapia-Rojas C, Rivera DS, Braidy N, Zolezzi JM, Godoy JA, Carvajal FJ, Ardiles AO, Bozinovic F, Palacios AG, Sachdev PS. (2015). Age progression of neuropathological markers in the brain of the Chilean rodent Octodon degus, a natural model of Alzheimer’s disease. Brain Pathol. 25:679-691.

Projects

2022-2024 CIES008 (PI: Alexies Dagnino) “Estrategias de afrontamiento al estrés durante el envejecimiento y su impacto en la memoria”.  (Co-investigador)

 2021-2023 FONDEF IdeA ID21I10153 (PI: Agustín Martínez). “Desarrollo de una cobertura cutánea costo efectiva “PanexpatchTM” para el tratamiento de úlceras venosas”. (Investigador)

2020-2022 FONDEF IdeA ID16I10223 (segunda etapa) (PI: Claudio Hetz). “Proteostaser-1: una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer” (Investigador).

FONDECYT REGULAR 1201342. “Over-activation of Panx1 in neurons leads to intracellular Ca2+ overload and subsequent defects in neuronal cytoskeleton and signaling receptor trafficking supporting synaptic defects in an Alzheimer´s disease model”.– Rol: Investigador responsable/ Adjudicado (2020-2024)

FONDECYT REGULAR 1200250. “Role of promigratory activation of VEGFR2 in the brain angiogenesis and its potential implication in learning and memory of offspring born to preeclampsia”.– Rol: co-investigador / Adjudicado (2020-2024)

Convenio de desempeño UVA1401 GERÓPOLIS, Universidad de Valparaíso. “Terapia Led Transcraneana aplicada a una población de adultos mayores portadores de enfermedad neurodegenerativa”– Rol: co-investigador / Adjudicado (2017-2019)

Conferences

“New insights into Alzheimer’s disease synaptotoxicity: the potential involvement of Pannexin 1 channels” organizado por el Instituto de Neurociencia de la Facultad de Ciencias.

“Rol de Panexina 1 en la enfermedad de Alzheimer”, Organizado por la comisión de investigación de la Facultad de medicina (23 de Octubre de 2018).

“La enfermedad de Alzheimer como una enfermedad del citoesqueleto neuronal: posible rol de los canales de Panexina 1”. Participación en Jornada de Investigación 2018, organizado por la vicerrectoria de investigación e innovación, Valparaíso (6 de Diciembre de 2018).

Participación en Ciclo de charlas: “Neurofisiología cerebral con énfasis en los vasos Sanguíneos”. Facultad de Ciencias Universidad del Bio Bio. (6-8 Noviembre de 2018).