Javier Bracchiglione


Department of Department of Public Health, School of Medicine, Universidad de Valparaíso, Chile.

Javier Bracchiglione graduated as a physician from the Universidad de Valparaíso and has a diploma in Primary Health Care and Family Medicine and a diploma in Evidence-Based Medicine from the Pontificia Universidad Católica de Chile. He completed his Master’s Degree in applied Clinical Research in Health Sciences at the Universitat Autònoma de Barcelona ​​and is currently undertaking a PhD in Biomedical Research and Public Health Methodology at that same university. He is a Professor at the Department of Department of Public Healthand the Head of the Research Office of the at Universidad de Valparaíso’s School of Medicine. In addition, he is a researcher at the Ibero-American Cochrane Centre at the Hospital de la Santa Creu i Sant Pau in Barcelona, ​​Spain. His work focuses primarily on health-related evidence synthesis.

Link research


Publicaciones en revistas científicas

Sgarbossa N, Ibáñez Cobaisse M, González Cianculli G, Bracchiglione J*, Franco JVA. Revisiones sistemáticas: conceptos clave para profesionales de la salud. Medwave. 2022 Oct 28. Available from:

Madrid E, Ocara Vargas M, Contreras-Vera C, Saldías C, Escobar Liquitay CM, Novik A V, Muñoz SR, Bracchiglione J. Glucagon-like peptide-1 analogues for overweight or obese adults. Cochrane Database of Systematic Reviews. 2022;9. Available from:

Bracchiglione J*, Meza N, Madrid E. Response to: “Additional considerations and response to Graphical Representation of Overlap for OVErviews (GROOVE tool).” Res Synth Methods [Internet]. 2022 Jul 7; Available from:

Bracchiglione J, Meza N, Franco JVA, Escobar Liquitay CM, Munoz SR, Urrutia G, Madrid E. Mapping Chilean clinical research: a protocol for a scoping review and multiple evidence gap maps. BMJ Open [Internet]. 2022 Jun 20;12(6):e057555. Available from:

Chamy V, Scarella-Chamy A, Oñate M, Guerra I, Palacios C, Concha V, Pérez-Bracchiglione J. Evaluación de la terapia de reproducción médicamente asistida en 9 años: estudio de cohorte retrospectivo. Rev Chil Obstet Ginecol [Internet]. 2022 May 25;87(2). Available from:

Pérez-Bracchiglione J*, Meza N, Bangdiwala SI, Niño de Guzmán E, Urrútia G, Bonfill X, Madrid E. Graphical Representation of Overlap for OVErviews: GROOVE tool. Res Synth Methods [Internet]. 2022 May;13(3):381–8. Available from:

Niño de Guzmán E, Martínez García L, González AI, Heijmans M, Huaringa J, Immonen K, Ninov L, Orrego-Villagrán C, Pérez-Bracchiglione J, Salas-Gama K, Viteri-García A, Alonso-Coello P. The perspectives of patients and their caregivers on self-management interventions for chronic conditions: a protocol for a mixed-methods overview. F1000Res [Internet]. 2020 Feb 18;9:120. Available from:

Stojanova J, Pérez-Bracchiglione J, Erridge S, Madrid E, Caracci B, Klabunde R, Franco JVA. Cannabis‐based medicines for prevention of postoperative nausea and vomiting in adults. Cochrane Database of Systematic Reviews. 2022;2. Available from:

Matus V, Kirmayr M, Retamal C, Vergara-Merino L, Kotlik A, Pérez-Bracchiglione J*. Embolización de la arteria renal: Serie de casos y revisión de la literatura. Revista de Cirugía [Internet]. 2022 Feb 8 [cited 2022 Jul 2];74(1). Available from:

Trivisonno LF, Escobar Liquitay C, Vergara-Merino L, Pérez-Bracchiglione J, Franco JVA. Key concepts for searching evidence: an introduction for healthcare professionals. Medwave [Internet]. 2022 Jan 7;22(1):e8512. Available from:

Vargas-Peirano M, Verdejo C, Vergara-Merino L, Loézar C, Hoehmann M, Pérez-Bracchiglione J. Intravitreal antivascular endothelial growth factor in diabetic macular oedema: scoping review of clinical practice guidelines recommendations. Br J Ophthalmol [Internet]. 2021 Dec 14; Available from:

Núñez-Cortés R, Alvarez G, Pérez-Bracchiglione J, Cabanas-Valdés R, Calvo-Sanz J, Bonfill X, Urrutia G. Reporting results in manual therapy clinical trials: A need for improvement. Int J Osteopath Med [Internet]. 2021 Dec;42:92–9. Available from:

Salazar J, Pérez-Bracchiglione J, Salas-Gama K, Antequera A, Auladell-Rispau A, Dorantes-Romandía R, Meade AG, Jesús Quintana M, Requeijo C, Rodríguez-Grijalva G, Santero M, Acosta-Dighero R, Solà I, Urrútia G, Bonfill Cosp X, Systemic Treatments for Advanced Digestive Cancer Research. Efficacy of systemic oncological treatments in patients with advanced pancreatic cancer at high risk of dying in the short or medium-term: overview of systematic reviews. Eur J Cancer [Internet]. 2021 Sep;154:82–91. Available from:

Vergara-Merino L, Meza N, Couve-Pérez C, Carrasco C, Ortiz-Muñoz L, Madrid E, Bohorquez-Blanco S, Pérez-Bracchiglione J. Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews. Acta Obstet Gynecol Scand [Internet]. 2021 Jul;100(7):1200–18. Available from:

Salas-Gama K, Díaz JM, Coronado J, Pérez-Bracchiglione J, Requeijo C, Samsó L, Suclupe S, Bolíbar I. Patient decision aids for adults with advanced chronic kidney disease with a medical recommendation to start dialysis: a scoping review protocol. JBI Evid Synth [Internet]. 2021 Jun 23;19(12):3347–54. Available from:

Santero M, Pérez-Bracchiglione J, Acosta-Dighero R, Meade AG, Antequera A, Auladell-Rispau A, Quintana MJ, Requeijo C, Rodríguez-Grijalva G, Salas-Gama K, Dorantes-Romandia R, Salazar J, Solà I, Urrútia G, Bonfill Cosp X. Efficacy of systemic oncological treatments in patients with advanced esophageal or gastric cancers at high risk of dying in the middle and short term: an overview of systematic reviews. BMC Cancer [Internet]. 2021 Jun 16;21(1):712. Available from:

Papuzinski C, Loézar C, Carvajal N, Vargas M, Borgeat M, Madrid E, Pérez-Bracchiglione J, Arancibia M. Inclusión de salud basada en evidencia en carreras de la salud en Chile y el modelo integrado Metodología de la Investigación Científica-Medicina Basada en Evidencia en la Universidad de Valparaíso. Educ médica [Internet]. 2021 Jun;22:179–84. Available from:

Quilodrán C, Kirmayr M, Valente B, Pérez-Bracchiglione J, Garegnani L, Franco JVA. The GRADE approach, Part 2: Evidence to decision frameworksoutlining decision-making in health. Medwave [Internet]. 2021 May 7;21(4):e8182. Available from:

Niño de Guzmán Quispe E, Martínez García L, Orrego Villagrán C, Heijmans M, Sunol R, Fraile-Navarro D, Pérez-Bracchiglione J, Ninov L, Salas-Gama K, Viteri García A, Alonso-Coello P. The Perspectives of Patients with Chronic Diseases and Their Caregivers on Self-Management Interventions: A Scoping Review of Reviews. Patient [Internet]. 2021 Nov;14(6):719–40. Available from:

Schuller-Martínez B, Meza N, Pérez-Bracchiglione J, Franco JVA, Loezar C, Madrid E. Graphical representation of the body of the evidence: the essentials for understanding the evidence gap map approach. Medwave [Internet]. 2021 Apr 23;21(3):e8164. Available from:

Meza N, Pérez-Bracchiglione J, Pérez I, Carvajal C, Ortiz-Muñoz L, Olguín P, Rada G, Madrid E, COVID-19 L·OVE Working Group. Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trials. Medwave [Internet]. 2021 Mar 3;21(2):e8105. Available from:

Verdejo C, Vergara-Merino L, Meza N, Pérez-Bracchiglione J, Carvajal-Juliá N, Madrid E, Rada G, Rojas Reyes MX. Macrolides for the treatment of COVID-19: a living, systematic review. Medwave [Internet]. 2020 Dec 14;20(11):e8074. Available from:

Loezar C, Pérez-Bracchiglione J, Arancibia M, Meza N, Vargas M, Papuzinski C, Rada G, Ondarza C, Jahr C, Cadena C, Madrid E. Guidelines in Low and Middle Income Countries Paper 2: Quality assessment of Chilean guidelines: need for improvement in rigor, applicability, updating, and patients’ inclusion. J Clin Epidemiol [Internet]. 2020 Nov;127:177–83. Available from:

Ricci-Cabello I, Vásquez-Mejía A, Canelo-Aybar C, Niño de Guzman E, Pérez-Bracchiglione J, Rabassa M, Rigau D, Solà I, Song Y, Neamtiu L, Parmelli E, Saz-Parkinson Z, Alonso-Coello P. Adherence to breast cancer guidelines is associated with better survival outcomes: a systematic review and meta-analysis of observational studies in EU countries. BMC Health Serv Res [Internet]. 2020 Oct 7;20(1):920. Available from:

Urrea G, Carvajal-Juliá N, Arcos C, Pérez-Bracchiglione J*. Physicians perspectives about medical sources of information: protocol for an overview of systematic reviews. Medwave [Internet]. 2020 Jun 9;20(5):e7921. Available from:

Niño de Guzmán E, Song Y, Alonso-Coello P, Canelo-Aybar C, Neamtiu L, Parmelli E, Pérez-Bracchiglione J, Rabassa M, Rigau D, Parkinson ZS, Solà I, Vásquez-Mejía A, Ricci-Cabello I. Healthcare providers’ adherence to breast cancer guidelines in Europe: a systematic literature review. Breast Cancer Res Treat [Internet]. 2020 Jun;181(3):499–518. Available from:

Colomina MJ, Bagó J, Pérez-Bracchiglione J, Nishishinya Aquino MB, Salas KR, Requeijo C, Urrútia G. Thromboprophylaxis in elective spinal surgery: A protocol for systematic review. Medicine [Internet]. 2020 May 22;99(21):e20127. Available from:

Madrid E, Barros Monge MJ, Urrútia G, Roqué i Figuls M, Pérez Bracchiglione J, Vargas Peirano M, Loézar Hernández CN, Bonfill Cosp X. Taxanes for advanced non-small cell lung cancer. Cochrane Libr [Internet]. 2018 Jul 13; Available from:

Martínez-Aguayo JC, Arancibia M, Meza-Concha N, Bustamante C, Pérez-Bracchiglione J, Madrid E. Brief psychosis induced by methylphenidate in a child with attention deficit disorder: a case report and literature review. Medwave [Internet]. 2017 Jun 21;17(5):e6980. Available from:


Minsal ID 757-79-LP21 DIPLAS. Contratación de servicios de búsqueda, extracción de datos, evaluación de riesgo de sesgo y síntesis de evidencia científica para guías de práctica clínica GES (2021-2022) Ministerio de Salud Subsecretaría de Salud Pública SBEETESA. Rol: Coordinadora e investigadora principal.

Commissioned Evidence Synthesis for the Gastroenteritis in Children Clnical Guideline Project.  :KSA Task Force/Elsevier (2022) Rol: Investigador/a

FONDECYT 1212037: “Mapping of chilean clinical health research through a systematic approach for identifying evidence gaps: A step towards evidence-informed decision making and strategic research agendas” (adjudicado a Universidad de Valparaíso. Investigadora responsable: Eva Madrid.

Proyecto FIS: Análisis y mejora de la adecuación de la prescripción de quimioterapia al final de la vida [PI18/00034]”. Instituto de Salud Carlos III. (Hospital de la Santa Creu i Sant Pau, España). 2019-2021.

European Union Horizon 2020. “COMPAR-EU Comparing self management interventions”. Investigadora principal: Rosa Suñol. Rol: Investigador valores y preferencias de pacientes mediante overviews de métodos mixtos.

Minsal ID 757-79-LP21   DIPLAS. Contratación de servicios de búsqueda, extracción de datos, evaluación de riesgo de sesgo y síntesis de evidencia científica para guías de práctica clínica GES (2021-2022) Ministerio de Salud Subsecretaría de Salud Pública SBEETESA. Rol: Investigador.

Resumen de políticas públicas para el control de fiebre Q. Asesoría para el Ministerio de Salud de Chile. Proyecto nacional, 2018.

Resumen de políticas: Evidencias para mejorar la tasa de vacunación del adulto mayor. Asesoría para el Ministerio de Salud de Chile y Organización Panamericana de la Salud. Proyecto nacional. 2017.