Alexies Dagnino


Profesor de la Universidad de Valparaíso.

Investigador del CIESAL.

Alexies Dagnino is a neurobiologist and full professor at the University of Valparaíso. He studied biochemistry at the Universidad Austral de Chile and then obtained a PhD in Biomedical Sciences at the Universidad de Chile. He has conducted several research stays where he specialised in the effects of stress on mental health at Stanford University (Salpolsky’s Lab, USA), the University of Texas at Dallas (Atzori’s Lab, USA) and the University of Brighton (Flint’s Lab, UK). Since 2011, he has been an academic at the Institute of Physiology of the Faculty of Science. His main area of research is the study of the neurobiological basis of resilience to stress and its relationship with the origin of mental illnesses such as depression and anxiety disorders.



Terreros G, Pérez MÁ, Muñoz-LLancao P, D’Espessailles A, Martínez EA, Dagnino-Subiabre A. The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats. Nutrients. 2024 Jan 27;16(3):381. doi: 10.3390/nu16030381.

Escobar AP, Bonansco C, Cruz G, Dagnino-Subiabre A, Fuenzalida M, Negrón I, Sotomayor-Zárate R, Martínez-Pinto J, Jorquera G. Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies. Int J Mol Sci. 2023 Jun 13;24(12):10083. doi: 10.3390/ijms241210083.

Rojas-Thomas F, Artigas C, Wainstein G, Morales JP, Arriagada M, Soto D, Dagnino-Subiabre A, Silva J, Lopez V. Impact of acute psychosocial stress on attentional control in humans. A study of evoked potentials and pupillary response. Neurobiol Stress. 2023 Jun 12;25:100551. doi: 10.1016/j.ynstr.2023.100551.

Burgueño AL, Astiz M, Dagnino-Subiabre A. Editorial: Early life stress and its impact on physiological fitness. Front Physiol. 2022 Oct 12;13:1037409. doi: 10.3389/fphys.2022.1037409.

Alvarado-Aravena C, Arriaza K, Castillo-Aguilar M, Flores K, Dagnino-Subiabre A, Estrada-Goic C, Núñez-Espinosa C. Effect of Confinement on Anxiety Symptoms and Sleep Quality during the COVID-19 Pandemic. Behav Sci (Basel). 2022 Oct 17;12(10):398. doi: 10.3390/bs12100398.

Dagnino-Subiabre A. Resilience to stress and social touch. Curr Opin Behav Sci. 2022 Feb;43:75-79. doi: 10.1016/j.cobeha.2021.08.011.

Bravo-Tobar ID, Fernández P, Sáez JC, Dagnino-Subiabre A. Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats. J Neurosci Res. 2021 Oct;99(10):2493-2510. doi: 10.1002/jnr.24902.

Walker SC, Cavieres A, Peñaloza-Sancho V, El-Deredy W, McGlone FP, Dagnino-Subiabre A. C-low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress. Eur J Neurosci. 2022 May;55(9-10):2925-2938. doi: 10.1111/ejn.14951.

Peñaloza-Sancho V, Pérez-Valenzuela C, Gonzalez C, Jujihara G, Bustos P, Dagnino-Subiabre A. Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats. Nutr Neurosci. 2021 Aug;24(8):583-600. doi: 10.1080/1028415X.2019.1

Dagnino-Subiabre A. Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism. Nutr Neurosci. 2021 Aug;24(8):624-634. doi: 10.1080/1028415X.2019.1661651.

Pérez MÁ, Morales C, Santander O, García F, Gómez I, Peñaloza-Sancho V, Fuentealba P, Dagnino-Subiabre A, Moya PR, Fuenzalida M. Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats. Front Cell Neurosci. 2019 Aug 20;13:372. doi: 10.3389/fncel.2019.00372.

Pérez-Valenzuela C, Terreros G, Dagnino-Subiabre A. Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia. Rev Neurosci. 2019 Apr 24;30(3):317-324. doi: 10.1515/revneuro-2018-0018.

Iturra-Mena AM, Arriagada-Solimano M, Luttecke-Anders A, Dagnino-Subiabre A. Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats. J Neuroendocrinol. 2018 Jul;30(7):e12609. doi: 10.1111/jne.12609.

Jorratt P, Delano PH, Delgado C, Dagnino-Subiabre A, Terreros G. Difference in Perseverative Errors during a Visual Attention Task with Auditory Distractors in Alpha-9 Nicotinic Receptor Subunit Wild Type and Knock-Out Mice. Front Cell Neurosci. 2017 Nov 8;11:357. doi: 10.3389/fncel.2017.00357.

Pérez MÁ, Peñaloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A. n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats. Nutr Neurosci. 2018 Oct;21(8):556-569. doi: 10.1080/1028415X.2017.1323609.

Pérez-Valenzuela C, Gárate-Pérez MF, Sotomayor-Zárate R, Delano PH, Dagnino-Subiabre A. Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats. Front Neural Circuits. 2016 Dec 27;10:108. doi: 10.3389/fncir.2016.00108.

Negrón-Oyarzo I, Dagnino-Subiabre A, Muñoz Carvajal P. Synaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood. Front Cell Neurosci. 2015 Nov 12;9:442. doi: 10.3389/fncel.2015.00442.

Cruz G, Riquelme R, Espinosa P, Jara P, Dagnino-Subiabre A, Renard GM, Sotomayor-Zárate R. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Horm Metab Res. 2014 May;46(5):322-7. doi: 10.1055/s-0033-1361159.

Negrón-Oyarzo I, Pérez MÁ, Terreros G, Muñoz P, Dagnino-Subiabre A. Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex. Behav Brain Res. 2014 Feb 1;259:342-53. doi: 10.1016/j.bbr.2013.11.001.



Ongoing projects and grants

  • 2023-2024. “Impact of stress resilience on cancer progression”. Global Fellowships Scheme, University of Brighton, UK. Grant Nº AP02 3010 G2452. Principal Investigator.
  • 2022-2024. “Strategies for coping with stress during aging and its impact on memory”. Consorcio de Universidades del Estado (CUECH) RED21993. Grant Nº CIES008. Principal Investigator.
  • 2022-2025. “Impact of the high n-6 polyunsaturated fatty acid intake and/or maternal obesity on neurodevelopment. Is there an essential contribution of dietary n-3 fatty acids?”. FONDECYT Regular Nº 1221098. Co-Investigator.
  • 2021-2024 . “El hiperandrogenismo durante el desarrollo prenatal y puberal altera las redes cerebrales funcionales comprometiendo la cognición social en hijas de mujeres con síndrome de ovario poliquístico: una hipótesis del doble golpe”. FONDECYT Regular Nº 1210261. Co-Investigador.

 Proyectos terminados:

  • 2021-2022 . “Papel de los receptores de glucocorticoides en los efectos a largo plazo de la resiliencia al estrés”. Beca Puente-UV Nº UVA20993. Investigador principal.
  • 2016-2019 . “De la presbiacusia a la demencia: una aproximación básica y clínica”. Beca Anillo de Investigación en Ciencia y Tecnología Nº ACT1403. Investigador principal.
  • 2014-2018 . “Efectos de los ácidos grasos n-3 y los endocannabinoides sobre el aprendizaje y la atención auditiva de ratas con estrés crónico”. FONDECYT Regular Nº 1141276. Investigador Principal.
  • 2010-2014. “Efectos de los tratamientos con antidepresivos y ambiente enriquecido sobre el deterioro inducido por el estrés en el sistema auditivo de las ratas”. FONDECYT Regular Nº 1100413. Investigador Principal.